Two sample MR report
HLA-A_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0269626 | 0.9318567 | 0.9783031 |
| Weighted median | 6 | -0.1370538 | 0.0434730 | 0.0016181 |
| Inverse variance weighted | 6 | -0.1430914 | 0.0354674 | 0.0000547 |
| Simple mode | 6 | -0.1340539 | 0.0566046 | 0.0640915 |
| Weighted mode | 6 | -0.1337827 | 0.0586861 | 0.0715710 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3093622 | 4 | 0.9892018 |
| Inverse variance weighted | 0.3427129 | 5 | 0.9967618 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.063281 | 0.346514 | 0.8639771 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001413 | 0 | TRUE | 0.2604855 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
